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It is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain).

Nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, or increased sweatingmay occur. If any of these effects persist or worsen, tell your doctor promptly.

Hypersensitivity to the drug and patients with closed angle glaucoma.

Before taking duloxetine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of psychiatric disorders (such as bipolar/manic-depressive disorder), personal or family history of suicide attempts, bleeding problems, personal or family history of glaucoma (angle-closure type), high blood pressure, kidney disease, liver disease, seizuredisorder, stomach problems (such as slow emptying of the stomach), use/abuse of alcohol.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Please consult your doctor when taking this medicine if you are pregnant.

MAOIs, such as isocarboxazid (Marplan), linezolid (Zyvox), and phenelzine (Nardil) Blood thinners, such as warfarin(Coumadin, Jantoven)